Models of neuroinflammation for the assessment of kappa-opioid receptor ligands

The development of new drugs to combat neuroinflammation is highly relevant as it opens up possibilities for the treatment a wide range diseases, including Alzheimer’s disease, Parkinson’s epilepsy, schizophrenia, depression, and others. Kappa-opioid agonists represent promising class compounds with а high potential be used in neurological conditions accompanied by neuroinflammation. aim study was provide summary current strategies employed evaluate neurotropic anti-inflammatory effects kappa-opioid ligands laboratory animals induced Materials methods. databases, such Google Scholar, PubMed, ScienceDirect, Scopus, e-Library were search tools. comprised following keywords phrases Russian English: kappa opioids + neuroinflammation; opioid receptors models; models rats, mice. 148 articles found, 122 included this review. Results. Various experimental neuroinflammation, chemically-induced bacterial endotoxin-induced well traumatic genetic mice rats evaluated. In addition, strengths limitations each model critically assessed identify most appropriate reliable approach investigating relationship between signaling pathways associated receptors. Conclusion. activity have been comprehensively described. review discusses both where investigated, properties not studied yet.